ykuQ [2019-07-31 14:18:37]

similar to tetrahydrodipicolinate succinylase

locus: BSU_14180

pI: 4.68

mw: 24.84 kDa

protein length: 236 aa

gene length: 711 bp

function: biosynthesis of lysine and peptidoglycan

product: similar to tetrahydrodipicolinate succinylase

essential: yes

ec: 2.3.1.89

synonyms: dapH

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.1|Biosynthesis of peptidoglycan]
• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.7|Biosynthesis/ acquisition of lysine/ threonine/ based on similarity]
• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.1|Biosynthesis of peptidoglycan]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

Gene

Coordinates: 1,488,973 1,489,683

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Catalyzed reaction/ biological activity

• Acetyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H₂O = CoA + L-2-acetamido-6-oxoheptanedioate (according to Swiss-Prot)

Protein family

• [SW|Transferase hexapeptide repeat family] (according to UniProt)

Structure

• [PDB|3R8Y] (from ''Bacillus anthracis'', 80% identity, 96% similarity)

Expression and Regulation

Operons

• genes: [gene|716FE06124544C05CC34BA2E643B4DBD27F04998|ykuQ]-[gene|D6F1906CE8386F78F451D6B794F74DE4AD25AC9C|ykuR]-[gene|3E7E0342AA86AFCC95F5CD5BEA5B10166DCE2721|ykuS]
  description: [Pubmed|22383849]

Biological materials

Mutant

• MGNA-B340 (ykuQ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1339 NBRP B. subtilis, Japan]